Cauterization of the root of the left coronary artery as a straightforward, large and reproducible ischemic injury model in neonatal mice.

ABSTRACT: The adult mammalian heart is known to have very limited regenerative capacity, explaining at least in part the frequency of cardiovascular diseases and their impact as the leading cause of death worldwide. By contrast, the neonatal heart has the ability to regenerate upon injury, and the molecular mechanisms underlying this regenerative capacity are intensely investigated to provide novel cues for the repair of the adult heart. However, the existing rodent neonatal injury models-apex resection, left anterior descending artery ligation and cryoinjury-have limitations, such as being technically demanding, yielding a nonphysiological injury type and/or lack of reproducibility. Here we have therefore established a novel ischemic heart injury method in neonatal mice via cauterization of the roo

SUBMITTER: Hu T 

PROVIDER: S-EPMC11518978 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature