Antibody-antibiotic conjugate targeted therapy for orthopedic implant-associated intracellular S. aureus infections.

ABSTRACT:

Introduction

Treating orthopedic implant-associated infections, especially those caused by Staphylococcus aureus (S. aureus), remains a significant challenge. S. aureus has the ability to invade host cells, enabling it to evade both antibiotics and immune responses during infection, which may result in clinical treatment failures. Therefore, it is critical to identify the host cell type of implant-associated intracellular S. aureus infections and to develop a strategy for highly targeted delivery of antibiotics to the host cells.

Objectives

Introduced an antibody-antibiotic conjugate (AAC) for the targeted elimination of intracellular S. aureus.

Methods

The AAC comprises of a human monoclonal antibody (M0662) directly recognizes the surface antigen of S. aureus, Staph

SUBMITTER: Qin L 

PROVIDER: S-EPMC11519013 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature