Spatial Similarity of MRI-Visible Perivascular Spaces in Healthy Young Adult Twins.

ABSTRACT:

Purpose

This study aimed to determine whether genetic factors affect the location of dilated perivascular spaces (dPVS) by comparing healthy young twins and non-twin (NT) siblings.

Materials and methods

A total of 700 healthy young adult twins and NT siblings [138 monozygotic (MZ) twin pairs, 79 dizygotic (DZ) twin pairs, and 133 NT sibling pairs] were collected from the Human Connectome Project dataset. dPVS was automatically segmented and normalized to standard space. Then, spatial similarity indices [mean squared error (MSE), structural similarity (SSIM), and dice similarity (DS)] were calculated for dPVS in the basal ganglia (BGdPVS) and white matter (WMdPVS) between paired subjects before and after propensity score matching of dPVS volumes between groups. Within-pair co

SUBMITTER: Lee B 

PROVIDER: S-EPMC11519134 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature