Targeted redox-responsive peptide for arterial chemoembolization therapy of orthotropic hepatocellular carcinoma.

ABSTRACT:

Objective

Transcatheter Arterial Chemoembolization (TACE) is the first choice for the treatment of advanced-stage hepatocellular carcinoma (HCC). However, TACE suffers from a lack of specificity and rapid drug release. Herein, a targeted redox-responsive peptide (TRRP) was synthesized and used as a carrier of doxorubicin (DOX) to enhance the efficacy of TACE through tumor cells targeting and controlled drug release.

Methods

TRRP has a high loading capacity of DOX and a sensitive drug release behavior at high glutathione (GSH) concentration. Moreover, TRRP could bind to the transferrin receptor on the surface of tumor cells, which enhanced the efficacy of TACE and reduced side effects of TACE. TACE with TRRP@DOX dispersed in lipiodol shows an enhanced therapeutic outcome comp

SUBMITTER: Xia Y 

PROVIDER: S-EPMC11519146 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature