Gut microbiota predict retinopathy in patients with diabetes: A longitudinal cohort study.

ABSTRACT: The gut microbiota has emerged as an independent risk factor for diabetes and its complications. This research aimed to delve into the intricate relationship between the gut microbiome and diabetic retinopathy (DR) through a dual approach of cross-sectional and prospective cohort studies. In our cross-sectional study cross-sectional investigation involving ninety-nine individuals with diabetes, distinct microbial signatures associated with DR were identified. Specifically, gut microbiome profiling revealed decreased levels of Butyricicoccus and Ruminococcus torques group, alongside upregulated methanogenesis pathways among DR patients. These individuals concurrently exhibited lower concentrations of short-chain fatty acids in their plasma. Leveraging machine learning models, including rand

SUBMITTER: Qin X 

PROVIDER: S-EPMC11519154 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature