Two-Dimensional "Nanotanks" Release "Gas Bombs" through Photodynamic Cascades to Promote Diabetic Wound Healing.

ABSTRACT: The emergence of multidrug-resistant (MDR) bacterial infections, particularly in diabetic wounds, represents a major challenge in clinical care due to their high mortality rate. Despite the continued use of antibiotics as the primary clinical treatment for diabetic wounds, there is an urgent need to develop antibiotic-free therapeutic strategies to combat MDR bacteria, given the limitations and resistance of antibiotics. In this study, a "nanotank", MXene@MOF@CORM-401 (MMC), was designed to target bacteria. The basis of this approach is the combination of 2-dimensional transition metal carbides/carbon nitrides (MXene), metal-organic frameworks (MOFs), and carbon monoxide-releasing molecules (CORMs). MMCs exhibit photothermal and photodynamic properties upon irradiation with near-infrared l

SUBMITTER: Zou J 

PROVIDER: S-EPMC11519204 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature