Solute carrier family 4 member 4 (SLC4A4) is associated with cell proliferation, migration and immune cell infiltration in colon cancer.

ABSTRACT:

Background

Solute Carrier Family 4 Member 4 (SLC4A4) is a membrane protein-coding gene for a Na⁺/HCO₃^- cotransporter and plays a crucial role in regulating pH, bicarbonate secretion and homeostasis. However, the prognostic and immunological role of SLC4A4 in colon cancer remains unknown.

Method

In this study, expression profiles of SLC4A4 were retrieved from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, to which a variety of bioinformatic analyses were performed. Sangerbox, Xiantao, ESTIMATE and TIMER online tools were used to delve into the relationship between SLC4A4 expression and immune cell infiltration. The role of SLC4A4 in the proliferation and migration of colon cancer cells was verified by CCK8, EdU and

SUBMITTER: Yu C 

PROVIDER: S-EPMC11519258 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature