Glucosinolates and Indole-3-carbinol from <i>Brassica oleracea</i> L. as inhibitors of <i>E. coli</i> CdtB: insights from molecular docking, dynamics, DFT and in vitro assay.

ABSTRACT: Escherichia coli (E. coli), a common human gut bacterium, is generally harmless but capable of causing infections and contributing to diseases like urinary tract infections, sepsis/meningitis, or diarrheal diseases. Notably, E. coli is implicated in developing gallbladder cancer (GBC) either through ascending infection from the gastrointestinal tract or via hematogenous spread. Certain E. coli strains are known to produce toxins, such as cytolethal distending toxins (CDTs), that directly contribute to the genetic mutations and cellular abnormalities observed in GBC. Broccoli (Brassica oleracea) is known for its health-promoting properties, including antimicrobial, antioxidant, and immunomodulatory effects, and is rich in essential compounds. Our study inv

SUBMITTER: Tasnim F 

PROVIDER: S-EPMC11519271 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature