An ovine septic shock model of live bacterial infusion.

ABSTRACT:

Background

Escherichia coli is the most common cause of human bloodstream infections and bacterial sepsis/septic shock. However, translation of preclinical septic shock resuscitative therapies remains limited mainly due to low-fidelity of available models in mimicking clinical illness. To overcome the translational barrier, we sought to replicate sepsis complexity by creating an acutely critically-ill preclinical bacterial septic shock model undergoing active 48-h intensive care management.

Aim

To develop a clinically relevant large-animal (ovine) live-bacterial infusion model for septic shock.

Methods

Septic shock was induced by intravenous infusion of the live antibiotic resistant extra-intestinal pathogenic E. coli sequence type 131 strain EC958 in eight anesthetis

SUBMITTER: Obonyo NG 

PROVIDER: S-EPMC11519284 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature