Targeting TREM2 signaling shows limited impact on cerebrovascular calcification.

ABSTRACT: Brain calcification, the ectopic mineral deposits of calcium phosphate, is a frequent radiological finding and a diagnostic criterion for primary familial brain calcification. We previously showed that microglia curtail the growth of small vessel calcification via the triggering receptor expressed in myeloid 2 (TREM2) in the Pdgfb ^ret/ret mouse model of primary familial brain calcification. Because boosting TREM2 function using activating antibodies has been shown to be beneficial in other disease conditions by aiding in microglial clearance of diverse pathologies, we investigated whether administration of a TREM2-activating antibody could mitigate vascular calcification in Pdgfb ^ret/ret mice. Single-nucleus RNA-sequencing analysis showed t

SUBMITTER: Sridhar S 

PROVIDER: S-EPMC11519321 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature