BACH1 as a key driver in rheumatoid arthritis fibroblast-like synoviocytes identified through gene network analysis.

ABSTRACT: RNA-sequencing and differential gene expression studies have significantly advanced our understanding of pathogenic pathways underlying rheumatoid arthritis (RA). Yet, little is known about cell-specific regulatory networks and their contributions to disease. In this study, we focused on fibroblast-like synoviocytes (FLS), a cell type central to disease pathogenesis and joint damage in RA. We used a strategy that computed sample-specific gene regulatory networks to compare network properties between RA and osteoarthritis FLS. We identified 28 transcription factors (TFs) as key regulators central to the signatures of RA FLS. Six of these TFs are new and have not been previously implicated in RA through ex vivo or in vivo studies, and included BACH1, HLX, and TGIF1. Several of these TFs were

SUBMITTER: Pelissier A 

PROVIDER: S-EPMC11519322 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature