Evaluation of anti-biofilm and anti-virulence effect of zinc sulfate on Staphylococcus aureus isolates.

ABSTRACT: Staphylococcus aureus produces a plethora of virulence factors to invade and establish infections in the host system, and biofilms are more resistant to antibiotics than planktonic cells. In this study, we aimed to investigate the anti-virulence and anti-biofilm potentials of zinc sulfate against S. aureus isolates. The synergistic effect of zinc sulfate in combination with antibiotics on S. aureus was characterized using the checkerboard method. The influence of zinc sulfate on biofilm formation and virulence factors production by S. aureus was experimentally assessed. RT-qPCR was used to investigate the effect of zinc sulfate on the expression of biofilm-related genes. Zinc sulfate exhibited good antibacterial activity against S. aureus with a MIC of 128 µg/ml against all tested isolates

SUBMITTER: Abdelraheem WM 

PROVIDER: S-EPMC11519333 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature