GFPT2: A novel biomarker in mesothelioma for diagnosis and prognosis and its molecular mechanism in malignant progression.

ABSTRACT:

Background

Mesothelioma (MESO) is an insidious malignancy with a complex diagnosis and a poor prognosis. Our study unveils Glutamine-Fructose-6-Phosphate Transaminase 2 (GFPT2) as a valuable diagnostic and prognostic marker for MESO, exploring its role in MESO pathogenesis.

Methods

We utilised tissue samples and clinicopathologic data to evaluate the diagnostic and prognostic significance of GFPT2 as a biomarker for MESO. The role of GFPT2 in the malignant progression of MESO was investigated through in vitro and in vivo experiments. The activation of NF-κB-p65 through O-GlcNAcylation at Ser⁷⁵ was elucidated using experiments like HPLC-QTRAP-MS/MS and mass spectrometry analysis.

Results

The study demonstrates that GFPT2 exhibits a sensitivity of 92.60% in d

SUBMITTER: Wei J 

PROVIDER: S-EPMC11519369 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature