Quantifying measurement uncertainty in renal transplant biopsy assessment.

ABSTRACT:

Introduction

Renal transplant biopsies provide insights into graft health and support decision making. The current evidence on links between biopsy scores and transplant outcomes suggests there may be numerous factors affecting biopsy scores. Here we adopt measurement science approach to investigate the sources of uncertainty in biopsy assessment and suggest techniques to improve its robustness.

Methods

Histological assessments, Remuzzi scores, biopsy processing and clinical variables are obtained from 144 repeat biopsies originating from 16 deceased-donor kidneys. We conducted sensitivity analysis to find the morphometric features with highest discriminating power and studied the dependencies of these features on biopsy and stain type. The analysis results formed a basis fo

SUBMITTER: Loizeau X 

PROVIDER: S-EPMC11519413 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature