Mechanical power is associated with cardiac output and pulmonary blood flow in an experimental acute respiratory distress syndrome in pigs.

ABSTRACT:

Background

Despite being essential in patients with acute respiratory distress syndrome (ARDS), mechanical ventilation (MV) may cause lung injury and hemodynamic instability. Mechanical power (MP) may describe the net injurious effects of MV, but whether it reflects the hemodynamic effects of MV is currently unclear. We hypothesized that MP is also associated with cardiac output (CO) and pulmonary blood flow (PBF).

Methods

24 anesthetized pigs with experimental acute lung injury were ventilated for 18 h according to one of three strategies: 1) Open lung approach (OLA), 2) ARDS Network high-PEEP/F_IO₂ strategy (HighPEEP), or 3) low-PEEP/F_IO₂ strategy (LowPEEP). Total MP was assessed as the sum of energy dissipated to overcome airway

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11519626 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature