Comparison of methods for cancer stem cell detection in prognosis of early stages NSCLC.

ABSTRACT:

Background

Despite advances in diagnosis and treatment in lung cancer, therapies still fail to improve patient management due to resistance mechanisms and relapses. As Cancer stem cells (CSCs) directly contribute to tumor growth and therapeutic resistance, their clinical detection represents a major challenge. However specific and additional CSC markers lack. Thus, our aim was to achieve selective detection of CSCs with specific glycan patterns and assess the CSCs burden to predict the risk of relapse in NSCLC tumors.

Methods

The lung CSCs detection and sorting with a lectin MIX were assessed and compared to CD133 in vitro. Then, its putative role as CSC biomarker was evaluated in vivo and its clinical significance on 221 NSCLC patients.

Results

We showed a significan

SUBMITTER: Chandouri B 

PROVIDER: S-EPMC11519646 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature