Inhaled Reliever Therapies for Asthma: A Systematic Review and Meta-Analysis.

ABSTRACT:

Importance

The optimal inhaled reliever therapy for asthma remains unclear.

Objective

To compare short-acting β agonists (SABA) alone with SABA combined with inhaled corticosteroids (ICS) and with the fast-onset, long-acting β agonist formoterol combined with ICS for asthma.

Data sources

The MEDLINE, Embase, and CENTRAL databases were searched from January 1, 2020, to September 27, 2024, without language restrictions.

Study selection

Pairs of reviewers independently selected randomized clinical trials evaluating (1) SABA alone, (2) ICS with formoterol, and (3) ICS with SABA (combined or separate inhalers).

Data extraction and synthesis

Two reviewers independently extracted data and assessed risk of bias. Random-effects meta-analyses synthesized outcomes.

SUBMITTER: Rayner DG 

PROVIDER: S-EPMC11519786 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature