Supramolecularly engineered bacteria mediated calcium overload and immunotherapy of tumors.

ABSTRACT: Intracellular Ca²⁺ nanogenerators, such as calcium carbonate, calcium peroxide, and calcium phosphate nanoparticles, have shown promise in calcium overload-mediated tumor therapy. However, their effectiveness is often hampered by poor targeting, low accumulation, and limited penetration into tumor cells, leading to suboptimal therapeutic outcomes. This strategy aims to achieve synergistic Ca²⁺ overload and immunotherapy of tumors. Methods: A supramolecular conjugate of engineered living bacteria (facultative anaerobic Salmonella typhimurium VNP20009, VNP) with CaCO₃ nanoparticles was developed for targeted delivery of curcumin-loaded CaCO₃ into tumors. Results: Both CaCO₃ nanoparticles and the loaded Ca²⁺ efflu

SUBMITTER: Xie B 

PROVIDER: S-EPMC11519789 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature