Role of damaged mitochondrial transfer in alpha-particle generator ²¹²Pb radiation-induced bystander effect.

ABSTRACT: Rationale: ²¹²Pb, a promising in vivo alpha-particle generator of ²¹²Bi, has aroused much interest as a therapeutic radionuclide. For the development of targeted alpha therapy (TAT), it is important to determine the contribution of targeted effects in irradiated cells, and also of non-targeted effects in non-irradiated bystander cells. Currently, the critical roles of mitochondrial transfer in cellular crosstalk have garnered significant attention. However, the specific involvement of damaged mitochondrial transfer in orchestrating this alpha-particle radiation-induced bystander effect (RIBE) needs to be further explored. Methods: A novel alpha-emitting radiopharmaceutical, ²¹²Pb-hydrogel nanoparticles (HNPs), was synthesized and

SUBMITTER: Yang M 

PROVIDER: S-EPMC11519793 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature