Recombinant Fibrous Protein Gels as Rheological Modifiers in Skin Ointments.

ABSTRACT: Rheological modifiers are an important component in the development of skin cream (SC) chassis for personal skin care products (PSCPs). The viscous behavior of a PSCP is critical to its effectiveness where its uniformity and material strength impact its processing, storage, and delivery of active ingredients. Due to the mildly acidic environment of the skin, PSCPs require a SC that will assist in maintaining their material strength at low pHs. We have investigated a coiled-coil protein hydrogel system for the ability to possess pH-responsiveness, where physical cross-linking and material strength is controlled by pH relative to the isoelectric point (pI) of the protein. We recently designed a coiled-coil protein hydrogel variant, Q5, which possesses a relatively low pI that we hypothesized

SUBMITTER: Britton D 

PROVIDER: S-EPMC11519833 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature