SON is an essential RNA splicing factor promoting ErbB2 and ErbB3 expression in breast cancer.

ABSTRACT:

Background

In breast cancer, ErbB receptors play a critical role, and overcoming drug resistance remains a major challenge in the clinic. However, intricate regulatory mechanisms of ErbB family genes are poorly understood. Here, we demonstrate SON as an ErbB-regulatory splicing factor and a novel therapeutic target for ErbB-positive breast cancer.

Methods

SON and ErbB expression analyses using public database, patient tissue microarray, and cell lines were performed. SON knockdown assessed its impact on cell proliferation, apoptosis, kinase phosphorylation, RNA splicing, and in vivo tumour growth. RNA immunoprecipitation was performed to measure SON binding.

Results

SON is highly expressed in ErbB2-positive breast cancer patient samples, inversely correlating with pat

SUBMITTER: Phillips JB 

PROVIDER: S-EPMC11519869 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature