Early inflammation as a footprint of increased mortality risk in infants living with HIV from three African countries.

ABSTRACT: In this work our aim was to identify early biomarkers in plasma samples associated with mortality in children with perinatal HIV treated early in life, to potentially inform early intervention targeting this vulnerable group. 20/215 children (9.3%) with perinatal HIV, enrolled within 3 months of age died prematurely within the first year of the study, despite early ART initiation. Using a propensity score, we selected 40 alive study participants having similar clinical and virological records compared to the deceased group. 13 HIV unexposed (HU) healthy children were additionally used as controls. Baseline plasma samples were analyzed using a targeted proteomic approach, and to assess pathogen-associated and damage-associated molecular patterns (PAMPs, DAMPs) levels. Data from deceased par

SUBMITTER: Morrocchi E 

PROVIDER: S-EPMC11519903 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature