The association of dietary insulinemic indices with PI3K, PTEN, and Akt gene expressions in visceral and subcutaneous adipose tissues among individuals undergoing abdominal surgery.

ABSTRACT:

Background/objective

The current study investigates the association between dietary insulinemic indices and Akt, PTEN, and PI3K gene expressions in visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) among individuals undergoing abdominal surgery.

Materials and methods

This cross-sectional study was conducted on 176 individuals, aged 18-84 years, who had undergone abdominal surgery. The participants were classified based on body mass index (BMI) as normal (BMI < 25 kg/m²), overweight (BMI = 25-29.9 kg/m²), and obese (BMI ≥ 30 kg/m²). The food frequency questionnaire was used to determine dietary glycemic and insulinemic indices. Real-time polymerase chain reaction was conducted for the expression of PI3K, PTEN, and Akt genes.<

SUBMITTER: Ahmadirad H 

PROVIDER: S-EPMC11519925 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature