Clinical epidemiology and impact of Haemophilus influenzae airway infections in adults with cystic fibrosis.

ABSTRACT:

Background

Haemophilus influenzae is prevalent within the airways of persons with cystic fibrosis (pwCF). H. influenzae is often associated with pulmonary exacerbations (PEx) in pediatric cohorts, but in adults, studies have yielded conflicting reports around the impact(s) on clinical outcomes such as lung function decline. Accordingly, we sought to discern the prevalence, natural history, and clinical impact of H. influenzae in adult pwCF.

Methods

This single-centre retrospective cohort study reviewed all adult pwCF with H. influenzae sputum cultures between 2002 and 2016. From this cohort, persistently infected subjects (defined as: ≥2 samples with the same pulsotype and > 50% sputum culture-positive for H. influenzae in each year) were matched (1:2) to controls without H.

SUBMITTER: Weyant RB 

PROVIDER: S-EPMC11520053 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature