Effect of heart rate control with ivabradine on hemodynamic in patients with sepsis: study protocol for a prospective, multicenter, randomized controlled trial.

ABSTRACT:

Introduction

Sepsis, a life-threatening syndrome, is often accompanied by tachycardia in spite of hypovolemia and hypotension have been corrected. Recently, relevant studies have shown that sustained tachycardia in sepsis was related to high mortality, and appropriate control of heart rate (HR) could improve prognosis. Ivabradine reduces HR directly without a negative inotropic effect through inhibition of the I_f ionic current, which is different from the traditional rate control drug (beta-blockers).

Methods and analysis

This is a prospective, multicenter, randomized, open label study designed to investigate the effect of heart rate control with ivabradine on hemodynamic in patients with sepsis. Our study will enroll 172 patients with sepsis as defined by The Thi

SUBMITTER: Zheng J 

PROVIDER: S-EPMC11520163 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature