Autonomic Dysfunction Among Adult Survivors of Childhood Cancer in the St. Jude Lifetime Cohort Study.

ABSTRACT:

Background

The burden and functional significance of autonomic dysfunction among survivors of childhood cancer is unknown.

Objectives

We evaluated the prevalence, risk factors, and functional relevance of autonomic dysfunction in survivors.

Methods

We conducted a cross-sectional prospective evaluation of 1,041 adult survivors of childhood cancer treated with anthracyclines (31.1%), chest-directed radiation (13.5%), both (19.5%), or neither (35.9%), and 286 community control subjects enrolled in the SJLIFE (St Jude Lifetime Cohort Study). Four measures of autonomic dysfunction were evaluated: elevated resting heart rate, decreased heart rate reserve, decreased systolic blood pressure response to exercise, and delayed heart rate recovery. Logistic regression tested asso

SUBMITTER: Groarke JD 

PROVIDER: S-EPMC11520214 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature