Multi-modal contrastive learning of subcellular organization using DICE.

ABSTRACT: The data deluge in biology calls for computational approaches that can integrate multiple datasets of different types to build a holistic view of biological processes or structures of interest. An emerging paradigm in this domain is the unsupervised learning of data embeddings that can be used for downstream clustering and classification tasks. While such approaches for integrating data of similar types are becoming common, there is scarcer work on consolidating different data modalities such as network and image information. Here, we introduce DICE (Data Integration through Contrastive Embedding), a contrastive learning model for multi-modal data integration. We apply this model to study the subcellular organization of proteins by integrating protein-protein interaction data and protein i

SUBMITTER: Nasser R 

PROVIDER: S-EPMC11520230 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature