Monomer unfolding of a bacterial ESCRT-III superfamily member is coupled to oligomer disassembly.

ABSTRACT: The inner membrane associated protein of 30 kDa (IM30), a member of the endosomal sorting complex required for transport (ESCRT-III) superfamily, is crucially involved in the biogenesis and maintenance of thylakoid membranes in cyanobacteria and chloroplasts. In solution, IM30 assembles into various large oligomeric barrel- or tube-like structures, whereas upon membrane binding it forms large, flat carpet structures. Dynamic localization of the protein in solution, to membranes and changes of the oligomeric states are crucial for its in vivo function. ESCRT-III proteins are known to form oligomeric structures that are dynamically assembled from monomeric/smaller oligomeric proteins, and thus these smaller building blocks must be assembled sequentially in a highly orchestrated manner, a sti

SUBMITTER: Quarta N 

PROVIDER: S-EPMC11520248 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature