Biosynthetic gene clusters from uncultivated soil bacteria of the Atacama Desert.

ABSTRACT: Soil microorganisms mediate several biological processes through the secretion of natural products synthesized in specialized metabolic pathways, yet functional characterization in ecological contexts remains challenging. Using culture-independent metagenomic analyses of microbial DNA derived directly from soil samples, we examined the potential of biosynthetic gene clusters (BGCs) from six bacterial communities distributed along an altitudinal gradient of the Andes Mountains in the Atacama Desert. We mined 38 metagenome-assembled genomes (MAGs) and identified 168 BGCs. Results indicated that most predicted BGCs were classified as non-ribosomal-peptides (NRP), post-translational modified peptides (RiPP), and terpenes, which were mainly identified in genomes of species from Acidobacterio

SUBMITTER: Andreani-Gerard CM 

PROVIDER: S-EPMC11520301 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature