Highly sensitive detection of alpha-fetoprotein using sandwich sensors.

ABSTRACT: Alpha-fetoprotein (AFP) is a crucial biomarker for detecting certain tumors across various demographics, including men, non-pregnant women, and children. However, existing detection methods often lack the desired sensitivity, necessitating the development of a straightforward, dependable, and highly sensitive AFP detection method. In this study, a novel approach utilizing a sandwich sensor system designed around the GDYO@AuNPs@PCN (graphdiyne oxide, gold nanoparticle, and porous coordination network) composite was proposed. The results revealed that this composite material, comprising three key components, offers superior quenching capabilities and heightened sensitivity to AFP compared to DNA sensors employing different nanomaterials. Leveraging the distinctive advantages and properties o

SUBMITTER: Xie B 

PROVIDER: S-EPMC11520321 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature