Positron emission tomography neuroimaging of [¹⁸F]fluorodeoxyglucose uptake and related behavior in the <i>Pink1</i>-/- rat model of Parkinson disease.

ABSTRACT:

Introduction

Parkinson disease (PD) is a neurodegenerative condition affecting multiple sensorimotor and cognitive systems. The Pink1-/- rat model exhibits vocal, cognitive, and limb use deficits seen in idiopathic PD. We sought to measure glucose metabolism in brain regions in Pink1-/- and wild type (WT) rats, and to associate these to measures of ultrasonic vocalization, cognition, and limb use behavior.

Methods

Pink1-/- (n = 12) and WT (n = 14) rats were imaged by [¹⁸F]fluorodeoxyglucose (FDG) positron emission tomography (PET) in a repeated measures design at approximately 10 months of age and 6 weeks later. Relative regional glucose metabolism was indexed by whole brain normalized FDG uptake, which was calculated for 18 regions identified

SUBMITTER: Converse AK 

PROVIDER: S-EPMC11520326 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature