Decoding the role of mycobacterial lipid remodelling and membrane dynamics in antibiotic tolerance.

ABSTRACT: Current treatments for tuberculosis primarily target Mycobacterium tuberculosis (Mtb) infections, often neglecting the emerging issue of latent tuberculosis infection (LTBI) which are characterized by reduced susceptibility to antibiotics. The bacterium undergoes multiple adaptations during dormancy within host granulomas, leading to the development of antibiotic-tolerant strains. The mycobacterial membrane plays a crucial role in drug permeability, and this study aims to characterize membrane lipid deviations during dormancy through extensive lipidomic analysis of bacteria cultivated in distinct media and growth stages. The results revealed that specific lipids localize in different regions of the membrane envelope, allowing the bacterium to adapt to granuloma conditions. Th

SUBMITTER: Menon AP 

PROVIDER: S-EPMC11520350 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature