Effect of cyclic topology <i>versus</i> linear terpolymers on antibacterial activity and biocompatibility: antimicrobial peptide avatars.

ABSTRACT: Host-defense peptides (HDPs) and their analogs hold significant potential for combating multidrug-resistant (MDR) bacterial infections. However, their clinical use has been hindered by susceptibility to proteases, high production costs, and cytotoxicity towards mammalian cells. Synthetic polymers with diverse topologies and compositions, designed to mimic HDPs, show promise for treating bacterial infections. In this study, we explored the antibacterial activity and biocompatibility of synthetic amphiphilic linear (LPs) and cyclic terpolymers (CPs) containing hydrophobic groups 2-ethylhexyl (E) and 2-phenylethyl (P) at 20% and 30% content. LPs were synthesized via RAFT polymerization and then cyclized into CPs through a hetero-Diels-Alder click reaction. The bioactivity of these terp

SUBMITTER: Aquib M 

PROVIDER: S-EPMC11520352 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature