Enhancing Ras cheese safety: antifungal effects of nisin and its nanoparticles against Aspergillus flavus.

ABSTRACT:

Background

Due to the adverse effects of industrial chemicals and their carcinogenicity and toxicity for humans, the debates have increased on using natural preservatives. This study was conducted to investigate the inhibitory effect of pure nisin and nisin nanoparticles (nisin NPs) against Aspergillus flavus in vivo by inoculation in laboratory-manufactured Ras cheese. A novel, safe, and natural approach of nanoprecipitation using acetic acid was employed to prepare nisin nanoparticles. The prepared NPs were characterized using zeta-sizer, FTIR, and transmission electron microscopy (TEM). Furthermore, the cytotoxicity of nisin NPs on Vero cells was assessed. The minimum inhibitory concentrations (MICs) of nisin and its nanoparticles were determined in vitro against A. flavus isola

SUBMITTER: Abd-Elhamed EY 

PROVIDER: S-EPMC11520377 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature