Sympathetic nerve signals: orchestrators of mammary development and stem cell vitality.

ABSTRACT: The mammary gland is a dynamic organ that undergoes significant changes at multiple stages of postnatal development. Although the roles of systemic hormones and microenvironmental cues in mammary homeostasis have been extensively studied, the influence of neural signals, particularly those from the sympathetic nervous system, remains poorly understood. Here, using a mouse mammary gland model, we delved into the regulatory role of sympathetic nervous signaling in the context of mammary stem cells and mammary development. Our findings revealed that depletion of sympathetic nerve signals results in defective mammary development during puberty, adulthood, and pregnancy, accompanied by a reduction in mammary stem cell numbers. Through in vitro three-dimensional culture and in vivo transplantati

SUBMITTER: Ye Z 

PROVIDER: S-EPMC11520406 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature