Cardiac corin and atrial natriuretic peptide regulate liver glycogen metabolism and glucose homeostasis.

ABSTRACT:

Background

Cardiovascular function and metabolic homeostasis are closely linked, but the underlying mechanisms are not fully understood. Corin is a protease that activates atrial natriuretic peptide (ANP), an essential hormone for normal blood pressure and cardiac function. The goal of this study is to investigate a potential corin and ANP function in regulating liver glycogen metabolism and glucose homeostasis.

Methods

Liver glycogen and blood glucose levels were analyzed in Corin or Nppa (encoding ANP) knockout (KO) mice. ANP signaling was examined in livers from Corin and Nppa KO mice and in cultured human and mouse hepatocytes by western blotting.

Results

We found that Corin and Nppa KO mice had reduced liver glycogen contents and increased blood glucose levels. B

SUBMITTER: Li W 

PROVIDER: S-EPMC11520433 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature