Marital dissolution and cognition: The mediating effect of Aβ neuropathology.

ABSTRACT:

Introduction

Widowhood and divorce are extremely stressful life events that are associated with dementia, but the neurobiological underpinnings of this risk remain unknown. Amyloid beta (Aβ) load may explain influences of chronic stress, commonly seen in disruptive marital transitions, on cognitive decline.

Methods

We examined whether Aβ quantified by tracer uptake on positron emission tomography mediates associations between marital dissolution and executive functioning and episodic memory performance using data from 543 cognitively normal (CN) participants from the Alzheimer's Disease Neuroimaging Initiative.

Results

Marriage dissolution was associated with increased Aβ burden (β = 0.56; P = 0.015) and worse memory performance (β = -0.09; P <

SUBMITTER: Chandra A 

PROVIDER: S-EPMC11520438 | biostudies-literature | 2024 Oct-Dec

REPOSITORIES: biostudies-literature