The association between benzodiazepine co-prescription, opioid agonist treatment and mortality: a systematic review.

ABSTRACT:

Background

Opioid agonist treatment (OAT) is the preferred treatment for opioid dependence due to benefits such as treatment retention, reduced opioid use and mortality. Benzodiazepine co-dependence is common in OAT patients and has been linked to increased mortality. Prescribing benzodiazepines during OAT has been tried to reduce the harms of extra-medical benzodiazepine use. This systematic review examines association between benzodiazepine co-prescription during OAT and mortality.

Methods

We searched MEDLINE, Embase, Psych INFO, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials and Epistemonikos for reports published from database inception to June 2021. The searches were updated in February 2024. We included studies comparing mortali

SUBMITTER: Hestevik CH 

PROVIDER: S-EPMC11520467 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature