Hoxa5 alleviates adipose tissue metabolic distortions in high-fat diet mice associated with a reduction in MERC.

ABSTRACT:

Background

Mitochondria-endoplasmic reticulum membrane contact (MERC) is an important mode of intercellular organelle communication and plays a crucial role in adipose tissue metabolism. Functionality of Hoxa5 is an important transcription factor involved in adipose tissue fate determination and metabolic regulation, but the relationship between Hoxa5 and MERC is not well understood.

Results

In our study, we established an obesity model mouse by high-fat diet (HFD), induced the alteration of Hoxa5 expression by adenoviral transfection, and explored the effect of Hoxa5 on MERC dysfunction and metabolic distortions of adipose tissue with the help of transmission electron microscopy, calcium ion probe staining, and other detection means. The results showed Hoxa5 was able to red

SUBMITTER: Chen Q 

PROVIDER: S-EPMC11520472 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature