Genomic insights into genes expressed specifically during infancy highlight their dominant influence on the neuronal system.

ABSTRACT:

Background

Elucidating the dynamics of gene expression across developmental stages, including the genomic characteristics of brain expression during infancy, is pivotal in deciphering human psychiatric and neurological disorders and providing insights into developmental disorders.

Results

Leveraging comprehensive human GWAS associations with temporal and spatial brain expression data, we discovered a distinctive co-expression cluster comprising 897 genes highly expressed specifically during infancy, enriched in functions related to the neuronal system. This gene cluster notably harbors the highest ratio of genes linked to psychiatric and neurological disorders. Through computational analysis, MYT1L emerged as a potential central transcription factor governing these genes. Re

SUBMITTER: Wang W 

PROVIDER: S-EPMC11520499 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature