Biogenic Ag-doped ZnO nanostructures induced cytotoxicity in luminal A and triple-negative human breast cancer cells.

ABSTRACT: Aim: To evaluate the apoptosis-inducing properties of undoped and silver-doped-zinc-oxide nanoparticles (SDZONs) synthesized using Boswellia serrata against MCF-7 (Luminal-A) and MDA-MB-231 (Triple-negative) breast cancer cell lines.Methodology: Nanostructures were developed by facile biohydrothermal method and characterized by x-ray diffraction (XRD), Fourier transform infrared (FTIR), and high resolution transmission electron microscopy (HR-TEM). The comparative effect of doping and dose concentration of nanostructures on cytotoxicity was measured using MTT and trypan-blue-exclusion assay.Results: SDZONs exhibited greater cytotoxicity (20.71%, 27.31% cell viability) as compared with undoped nanostructures (35.81%, 37.08% cell viability) against MCF 7 and MDA-M

SUBMITTER: Banthia P 

PROVIDER: S-EPMC11520553 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature