Human-specific protein-coding and lncRNA genes cast sex-biased genes in the brain and their relationships with brain diseases.

ABSTRACT:

Background

Gene expression shows sex bias in the brain as it does in other organs. Since female and male humans exhibit noticeable differences in emotions, logical thinking, movement, spatial orientation, and even the incidence of neurological disorders, sex biases in the brain are especially interesting, but how they are determined, whether they are conserved or lineage specific, and what the consequences of the biases are, remain poorly explored and understood.

Methods

Based on RNA-seq datasets from 16  and 14 brain regions in humans and macaques across developmental periods and from patients with brain diseases, we used linear mixed models (LMMs) to differentiate variations in gene expression caused by factors of interest and confounding factors and identify four types of

SUBMITTER: He S 

PROVIDER: S-EPMC11520681 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature