Synergistic potential of Leu₁₀-teixobactin and cefepime against multidrug-resistant Staphylococcus aureus.

ABSTRACT: Staphylococcus aureus (S. aureus) is a significant Gram-positive opportunistic pathogen behind many debilitating infections. β-lactam antibiotics are conventionally prescribed for treating S. aureus infections. However, the adaptability of S. aureus in evolving resistance to multiple β-lactams contributed to the persistence and spread of infections, exemplified in the emergence of methicillin-resistant S. aureus (MRSA). In the present study, we investigated the efficacies of the synthetic teixobactin analogue, Leu₁₀-teixobactin, combined with the penicillinase-resistant cephalosporin cefepime against MRSA strains. The Leu₁₀-teixobactin and cefepime combination exerted synergism against most strains tested in broth microdilution assay. Time-kill profiles showed that bo

SUBMITTER: Koh AJJ 

PROVIDER: S-EPMC11520699 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature