A fast protocol for multicenter and multiparametric quantitative MRI studies in brain tumor patients using vendor sequences.

ABSTRACT:

Background

Multiparametric quantitative MRI (mp-qMRI) provides noninvasive, quantitative measurements sensitive to a variety of tissue properties. In brain tumors (BTs), longitudinal relaxation time (T1), effective transverse relaxation time (T2*), transverse relaxation time (T2), water content (H₂O), and quantitative susceptibility (χ) give valuable insights into the microenvironment. To generate large multicenter datasets, protocols need to be short and implementable on any scanner. The goal of this work was to develop and validate an 8-min, 3T mp-qMRI protocol for BT patients solely using generalized pulse sequences (mGRE and EPI).

Methods

A protocol was developed and tested on a multicompartment phantom, 5 healthy subjects (mean age: 31.64 years), and 4

SUBMITTER: Thomas DC 

PROVIDER: S-EPMC11520745 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature