Evaluating the therapeutic potential of different sources of mesenchymal stem cells in acute respiratory distress syndrome.

ABSTRACT:

Background

Mesenchymal stem/stromal cells (MSCs) have attracted interest as a potential therapy given their anti-inflammatory and immunomodulatory properties. However, clinical trials using MSCs for acute respiratory distress syndrome (ARDS) have produced mixed and inconclusive data. In previous work, we performed a "head-to-head" comparison between different sources of MSCs and showed that each source had a unique genomic and proteomic "signature".

Method

This study investigated which sources of MSC: bone marrow derived-MSCs (BM-MSCs), adipose tissue derived-MSCs (AD-MSCs) and umbilical cord derived-MSCs (UC-MSCs)  would be the optimal candidate to be used as a therapy in an LPS-induced mouse model of ARDS. Immune cells assessment, tissue transcriptomics, animal survival, a

SUBMITTER: Regmi S 

PROVIDER: S-EPMC11520775 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature