VEGFB ameliorates insulin resistance in NAFLD via the PI3K/AKT signal pathway.

ABSTRACT:

Background

Non-alcoholic fatty liver disease (NAFLD) is one of the most universal liver diseases with complicated pathogenesis throughout the world. Insulin resistance is a leading risk factor that contributes to the development of NAFLD. Vascular endothelial growth factor B (VEGFB) was described by researchers as contributing to regulating lipid metabolic disorders. Here, we investigated VEGFB as a main target to regulate insulin resistance and metabolic syndrome.

Methods

In this study, bioinformatics, transcriptomics, morphological experiments, and molecular biology were used to explore the role of VEGFB in regulating insulin resistance in NAFLD and its molecular mechanism based on human samples, animal models, and cell models. RNA-seq was performed to analyze the signal p

SUBMITTER: Li Y 

PROVIDER: S-EPMC11520811 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature