Exploring potential therapeutic targets for asthma: a proteome-wide Mendelian randomization analysis.

ABSTRACT:

Background

Asthma poses a significant global health challenge, characterized by high rates of morbidity and mortality. Despite available treatments, many severe asthma patients remain poorly managed, highlighting the need for novel therapeutic strategies. This study aims to identify potential drug targets for asthma by examining the influence of circulating plasma proteins on asthma risk.

Methods

This study employs summary-data-based Mendelian randomization (MR) and two-sample MR methods to investigate the association between 2940 plasma proteins from the UK Biobank study and asthma. The analysis includes discovery (FinnGen cohort) and replication (GERA cohort) phases, with Bayesian colocalization used to validate the relationships between proteins and asthma. Furthermore, p

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC11520847 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature