Integration of bioinformatics and cellular experiments unveils the role of SYT12 in gastric cancer.

ABSTRACT:

Objective

This study employs integrated bioinformatics analysis and in vitro cellular experiments to elucidate the role of Synaptotagmin-12 (SYT12) in the progression of gastric cancer.

Methods

We utilized databases and platforms such as Xiantao Academic Tools, UALCAN, Kaplan-Meier plotter analysis, and The Cancer Genome Atlas (TCGA) to extract datasets on SYT12 in gastric cancer. We analyzed the relationship between SYT12 expression and the clinicopathological features, prognosis, diagnosis, and immune infiltration of stomach adenocarcinoma (STAD) patients. Verification was conducted using samples from 31 gastric cancer patients. Additionally, in vitro cellular experiments were performed to determine the role and potential mechanisms of SYT12 in the malignant behavior of ga

SUBMITTER: Niu X 

PROVIDER: S-EPMC11520883 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature