TRPV1 alleviates APOE4-dependent microglial antigen presentation and T cell infiltration in Alzheimer's disease.

ABSTRACT:

Background

Persistent innate and adaptive immune responses in the brain contribute to the progression of Alzheimer's disease (AD). APOE4, the most important genetic risk factor for sporadic AD, encodes apolipoprotein E4, which by itself is a potent modulator of immune response. However, little is known about the immune hub that governs the crosstalk between the nervous and the adaptive immune systems. Transient receptor potential vanilloid type 1 (TRPV1) channel is a ligand-gated, nonselective cation channel with Ca²⁺ permeability, which has been proposed as a neuroprotective target in AD.

Methods

Using Ca²⁺-sensitive dyes, dynamic changes of Ca²⁺ in microglia were measured, including exogenous Ca²⁺ uptake and endoplasmic reticulum

SUBMITTER: Lu J 

PROVIDER: S-EPMC11520887 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature