Deciphering Host-Parasite Interplay in <i>Leishmania</i> Infection through a One Health View of Proteomics Studies on Drug Resistance.

ABSTRACT: Recent efforts in the study of vector-borne parasitic diseases (VBPDs) have emphasized an increased consideration for preventing drug resistance and promoting the environmental safety of drugs, from the beginning of the drug discovery pipeline. The intensive use of the few available antileishmanial drugs has led to the spreading of hyper-resistant Leishmania infantum strains, resulting in a chronic burden of the disease. In the present work, we have investigated the biochemical mechanisms of resistance to antimonials, paromomycin, and miltefosine in three drug-resistant parasitic strains from human clinical isolates, using a whole-cell mass spectrometry proteomics approach. We identified 14 differentially expressed proteins that were validated with their transcripts. Next, we employ

SUBMITTER: Tagliazucchi L 

PROVIDER: S-EPMC11520909 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature